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Anti-Inflammatory and Hepatoprotective Effects of the Homogenate of Cucumis Sativus (Cucumber) Fruits

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Description

Download Anti-Inflammatory and Hepatoprotective Effects of the Homogenate of Cucumis Sativus (Cucumber) Fruits. Biochemistry students who are writing their projects can get this material to aid their research work.

Abstract

Research on inflammation has become the focus of global scientific study because of its implication in virtually all human and animal diseases.

Also, liver diseases have been on increase and of global concern.Cucumis sativus is believed to have anti-oxidant activity, high flavonoid content, anti-inflammatory and analgesic effect, which may be likely of use in the management of these diseases.

The anti-inflammatory and hepatoprotective effects of the homogenate of Cucumis sativus fruit were therefore studied.

The fresh fruit of Cucumis sativus was homogenized and used for all experimental analysis without further dilution. Acute toxicity tests of the homogenate of Cucumis sativusfruit were carried out.

The phytochemical analyses and proximate compositions of the fruit homogenate were carried out. 1, 1-Diphenyl-2-Picryl Hydrazyl (DPPH) radical scavenging activity of the fruit homogenate was determined. The effects of the fruit homogenate on agar-induced paw oedema in rats were investigated.

Introduction

In most rural communities of developing countries, plant materials are sources of shelter, food and medicinal compounds (Oduolaet al., 2005).

Herbal medicine is fast emerging as an alternative treatment to available synthetic drugs for the treatment of disease possibly due to lower cost, availability, fewer adverse effect and perceived effectiveness (Ubakaet al., 2010).

The World Health Organization (WHO) has shown great interest in plant derived medicines which have been described in the folklore medicines of many countries (Mukherjee, 2002).

However, the historic role of medicinal plants in the treatment and prevention of diseases and their role as catalyst in the development of pharmacology do not assure their safety for uncontrolled use by an uninformed public (Matthew et al., 1999).

It is thus, imperative that plant products, which have been used from ages, have scientific support for their efficacy. Medicinal plants with anti-inflammatory activity are considerably employed in the treatment of several inflammatory disorders (Iwuekeet al., 2006).

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