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Assessment of Serum Cystatin C, Creatinine and Estimated Glomerular Filtration Rate in Patients with Chronic Kidney Disease in Zaria, Nigeria 

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– Assessment of Serum Cystatin C, Creatinine and Estimated Glomerular Filtration Rate in Patients with Chronic Kidney Disease in Zaria, Nigeria –

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Abstract

The limitations of serum creatinine as a marker of impairment in GFR have led to continuing search for a better marker.

Most studies have shown that serum cystatin C may be a more sensitive indicator of glomerular filtration rate (GFR) than serum creatinine in the clinical setting.

This study was designed to evaluate serum cystatin C,creatinineand estimated GFR (eGFR)in Chronic Kidney Disease (CKD) patients.

One hundred and fourteen (114) CKD Patients (comprising 59 males and 55 females) attending Nephrology Clinic at ABUTH and apparently healthy age and sex matched controls were recruited for the study.

Serum creatinine and cystatin C were assayed by the Jaffe kinetic and immunoturbidimetric methods respectively. Estimated GFR was calculated usingthe Cockcroft-Gault (C-G) formula.

Introduction

Chronic kidney disease (CKD) is defined by the occurrence of kidney damage or glomerular filtration rate (GFR) <60 mL/min/1.73 m2 for ≥3 months.

According to the definition by the Kidney Disease Outcome Quality Initiative (K/DOQI) (2002), the presence of CKD should be established base on the occurrence of kidney damage and the level of kidney function, regardless of the specific diagnosis of diseases and conditions causing the damage.

Disease staging is based on the GFR (Table 1.1). Chronic kidney disease is characterized by a gradual and permanent loss of kidney function that worsens as it progresses from stages 1 to 5 (National Kidney Foundation. K/DOQI 2002).

The global increase in the incidence and prevalence of CKD is being driven by the global increase in the prevalence of diabetes mellitus, hypertension, obesity, and aging.

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