– Comparative Effects of Nigella Sativaseed Oil And Zinc Gluconate Onethanol-Induced Gastric Mucosal Damage And Secretion In Wistar Rats –
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A wide spread search has been launched to identify new anti-ulcer therapies from naturalsources, with minimal side effects. The aim of the study was to compare the effects ofNigella sativaseed oil and zinc gluconate on ethanol-induced gastric mucosal damage andsecretion in Wistar rats.
A total of 50 male rats, weighing between 150-200g were used forthe study. The animals were then sub-divided into two sub-groups of 25 rats each forgastric mucosal damage and gastric secretion studies respectively.
Each of the sub-groupswere divided into 5 groups of 5 rats each and treated with distilled water (10ml/kg),absoluteethanol (1ml/kg),Nigella sativa oil (5ml/kg), zinc gluconate (50mg/kg) and zincgluconate (50mg/kg) plus Nigella sativa oil (5ml/kg) respectively.
The phythochemicalscreening of the Nigella sativa oil revealed the presence of carbohydrate, unsaturatedsteroids, triterpenes, cardiac glycoside and flavonoids.
The results of the study revealed thenormal architecture of gastric mucosa for the control group with ulcer index of 0.0 ± 0.0mm. The ethanol-treated group showed severe necrosis-of gastric epithelium,with ulcerindex of 10.25± 0.85 mmas compared to the control.
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