Comparative Evaluation of Soybean (Glycine max L) Extracts and Oestrogen Cream on Experimental Cutaneous Wound Healing in Ovariectomized Albino Rats

Description

– Comparative Evaluation of Soybean (Glycine max L) Extracts and Oestrogen Cream on Experimental Cutaneous Wound Healing in Ovariectomized Albino Rats –

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Abstract

This study was carried out to evaluate the comparative effects of topical soybeans extracts and oestrogen cream on cutaneous wound healing using excision wound model in ovariectomized Wistar albino rats.

Twenty four (24) female Wistar albino rats of age 20 weeks weighing 200-250g were ovariectomised two weeks post acclimatisation and monitored for four weeks post-surgery for proper recovery.

They were randomly divided into four groups (A, B, C, D) with 6 rats in each group. Two full-thickness skin excision measuring 1.5 x 1.5cm was surgically created at the dorsum of the thoraco-abdominal region of each rat.

Wounds in all groups (A, B, C, D) were monitored and treated topically with normal saline, oestrogen cream, soybean crude-ethanolic extract and Soybean- chloroform extract respectively, for 20 days.

Introduction

A wound involves the disruption (sequel to damage) of the normal continuity to an epithelial surface and its underlying connective tissues (Dunnill et al., 2017) and it is one of the most frequent reasons for seeking medical attention (Kokane et al., 2009).

An impaired wound healing is a major area of unmet clinical need that constitutes a substantial drain on global health services and leads to significant patient morbidity (Campbell et al., 2010).

Wound healing is an important process in replacement of tissue structure and function (Rubin and Farber, 1994; Reddy et al, 2008), restoration of dermal barrier and preventing infection following injury (Gilliver et al., 2006).

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