– Design and Development of a Starch-Based Multifunctional Excipient (Stargelasil) for Tablet Formulation –
Download Design and Development of a Starch-Based Multifunctional Excipient (Stargelasil) for Tablet Formulation. Pharmacognosy students who are writing their projects can get this material to aid their research work.
The concept of co-processing as a particle engineering technique has been used as a tool to improve the functionality of many existing excipients. This study was designed to improve the functionality of cassava starch as excipient for direct compression by coprocessing with gelatin and colloidal silicon dioxide.
The Design of Experiment (DoE) approach was employed to optimize the percentage ratios of the primary excipients for the co-processed excipient.
Fourteen experimental formulations containing varying proportions of the primary excipients were prepared by the method of co-fusion and twelve tablets each weighing 400 mg each were produced for each formulation using the Hydraulic Carver Press.
The compressed tablets were kept for 24 h in the desiccator and evaluated for tensile strength and disintegration time.
The data obtained from the tablets were suitably analysed using the Design Expert software and fitted to a special quartic model that correlated the effect of varying the proportions of the excipients in the different formulations on tablet properties.
Tablets account for more than 80 % of all dosage forms in the market (Khomane and Bansal, 2013)because of the following properties:
(i) They are easy to dispense,
(ii) Offer dosage accuracy,
(iii) They are amenable to mass production at a relatively cheap cost,
(iv) Tamper resistant compared to capsules, and
(v) Offer better stability to heat and moisture compared to liquid and semi-solid formulations (Jivraj et al., 2000; Pucelj, 2014).
The European Pharmacopoeia (2002) defines tablets as solid preparations each containing a single dose of one or more active substances and usually obtained by compressing uniform volumes of particles.
Tablets are intended for oral administration. Some are swallowed whole, some after being chewed, some are dissolved or dispersed in water before being administered and some are retained in the mouth where the active substance is liberated.
Despite the long and continuing history of the development of new technologies for administration of drugs, the tablet form remains the most commonly used dosage form (European Pharmacopoeia, 2002).
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