Determination of Thyroid Hormonal Levels in HIV Positive Individuals in Nsukka Community of South Eastern Nigeria
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Determination of Thyroid Hormonal Levels in HIV Positive Individuals in Nsukka Community of South Eastern Nigeria

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Abstract

This study assessed the levels of cluster determinant 4 (CD4 + ) cell, total protein, triacylglycerol (TAG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C),

thyroid stimulating hormone (TSH) and thyroxine (T4), of one hundred (100) subjects of which twenty-four (24) were healthy subjects which represented normal control (Group1),

twenty-eight (28) were HIV-positive subjects who were on treatment with administration of antiretroviral therapy (ART) as Group 2 and forty-eight (48)

were HIVpositive subjects who were not on treatment with antiretroviral therapy (NART) (Group 3) and also to correlate the variation in total protein and lipid profile with the CD4 + cell count for each of the study groups.

Introduction

The acquired immunodeficiency syndrome (AIDS) is a disease of the human immune system caused by infection with a retrovirus known as the human immunodeficiency virus (HIV) (Sepkowitz, 2001).

The virus breaks down the body’s immune system, infects CD4 + cells initially and progressively leads to AIDS (Rasool et al., 2008).

The CD4 + cells also known as T-helper cells are a type of white blood cells that play important roles in the immune system. CD4 + cells are made in the spleen, lymph nodes, and thymus gland, which are part of the lymph or infectionfighting system.

These helper cells move throughout the body, helping to organize the immune system’s response to bacteria, fungi and viruses (Fevrier et al., 2011).

CD4 + cell counts alongside other parameters are of central importance in the monitoring of immune function (Aina et al., 2005). The CD4 + lymphocyte is the primary target of HIV infection because of the affinity of the virus to the CD4 + surface marker and also its ability to enter CD4 + cells and become part of them

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