– Effects of the Methanolic Leaf Extract of Palisota Hirsuta in Post-Surgical Wound Management –
Download Effects of the Methanolic Leaf Extract of Palisota Hirsuta in Post-Surgical Wound Management. veterinary Surgery students who are writing their projects can get this material to aid their research work.
This study evaluated the use of the methanolic leaf extract of Palisota hirsuta in postsurgical wound management using different wound models in rats. It also assessed the antibacterial activity of the plant extract as well as the possible toxic effects on the liver, kidney and blood.
The yield of the methanolic leaf extract of Palisota hirsuta (PHLE) was 5.98 % w/w and it was dark green, pasty in consistency with a pungent smell. In the excision wound model, PHLE at 1% and 4 % significantly (p<0.05) increased the percentage wound contraction from days 6 – 21 post-surgery when compared with Petroleum Jelly and Cicatrin®.
The PHLE –treated rats in group V (4 % PHLE) showed best activity in wound contraction when compared with rats in groups III (1 % PHLE) and IV (2 % PHLE) throughout the duration of the experiment.
The epithelialization period of the PHLE-treated rats in group V (4 %) was significantly (p<0.05) lower than those of the control groups I and II.
The restoration of function is of fundamental importance in surgery. This is based on cells and tissues regaining biologic integrity through healing from wounds created naturally or iatrogenically (Harari, 2004).
Wounds represent a significant burden on the patients and health care professionals worldwide in that not only do they affect the physical and mental health of millions of people; they also impose significant cost on them (Badri and Renu, 2011).
Presently, estimates show that nearly 6 million people worldwide suffer from chronic wounds (Kumar et al., 2007), which have failed to progress through the normal stages of healing thereby entering a state of pathologic inflammation (Menke et al., 2007).
These wounds may even lead to multiple organ failure or death of the patient (Roberts et al., 1998).
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