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Epidemiology, Chemotherapy of Onchocerciasis and Development of Onchocerca-specific Polymerase Chain Reaction Based on a Pglycoprotein Gene

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Description

Download Epidemiology, Chemotherapy of Onchocerciasis and Development of Onchocerca-specific Polymerase Chain Reaction Based on a Pglycoprotein Gene. Zoology students who are writing their projects can get this material to aid their research work.

Abstract

Onchocerciasis is a disease caused by a filarial nematode Onchocerca volvulus, which is transmitted to man through the bite of infected black flies of the Simulium damnosum complex.

In Achi community (South Eastern Nigeria) – ivermectin treatments started since 1990 on a yearly basis under the auspices of a WHO/UNDP/WORLD BANK ONCHO. PROJECT.  

During this study in Achi and Amansea, the participants medical history, onchocercomata and skin snips were obtained between January, 2009 to December, 2012 from the studied groups.

The studied population of 240 subjects was randomly selected thus: Achi (57), Amansea (52) and UNTH (131) (health seeking patients at Oncho. Project, University of Nigeria Teaching Hospital).  

The studied groups were out patients of the WHO/UNDP/World Bank Oncho Project in the various villages. The patients were grouped into age, sex, occupation, residence, dosage levels, skin microfilariae and degrees of onchodermatitis.

Introduction

Onchocerciasis is the disease resulting from infection with the filarial nematode Onchocerca volvulus, which is transmitted to man through the bite of the infected black flies belonging to the genus, Simulium (Family: Simuliidae) (WHO, 1991, Okuliez, 2008).

The global distribution of onchocerciasis includes endemic areas in tropical Africa, where 99% of the total infected persons are found, Central and South America (WHO, 1987).  

It is estimated that 85.5 million people are at risk and that 17.7 million people are infected with O. Volvulus (WHO, 1995). Onchocerciasis is one of the leading causes of loss of sight in the world, responsible for about 270,000 blind and 500 000 partly sighted people (WHO, 1995).

The current global burden of the disease showed that an estimated 123 million persons were at risk of contracting the disease and 17 – 18 million were infected (WHO, 1999; Hoerauf et al., 2003; Boatin and Richrads, 2006). 

 According to IJPD (2009), more than 30 million Nigerians in 32 states and the Federal Capital Territory are estimated to be at risk for onchocerciasis.

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