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Phytochemical and Biological Studies Of Ethanol Extract Of Chrozophora Senegalensis (Lam) A. Juss

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Abstract

The ethanol extract of root of Chrozophora senegalensis use in ethanomedicine to treat diarrhea, rheumatism, taeniasis, stomach ache, inflammation and veneral diseases was subjected to Phytochemical and Biological studies.

Phytochemical analysis was carried out using standard phytochemical procedures which revealed the presence of flavonoids, tannins, alkaloids, saponins.

Chromatographic separation of the ethylacetate fraction using silica gel led to the isolation of three compounds, identified as 5-hydroxy – 2- (4-hydroxyphenol) – 4 – chromenone – 7- glucose (Apigenin – 7- O- glucoside);

5,7 – dihydroxy-2- (4 hydroxyphenyl) – 4 – chromenone – 3 – glucose (Aromadendrin -3-O-glucoside) and 2 – (3,4 – dihydroxy phenyl) – 3,5,7 – trihydroxy 4 H – chromen 4 – one (Quercetin) using spectrocopic analysis.

The mean number of writhing in acetic acid induced-writhing in mice is 18.8 with normal saline while at dose of 600, 300 and 150mg/kg of ethanol extract has 1.3,1.7 and 3.7 respectively. The standard drug (ketoprofen, 10mg/kg) has 0.6 mean number of writhing.

Introduction

The term “traditional medicine” refers to ways of protecting and restoring health that existed before the arrival of modern medicine (WHO,1996).

As the term implies, these approaches to health belong to the traditions of each country, and have been handed down from generation to generation.

In practice, the term “traditional medicine” refers to the following components: acupuncture, traditional birth attendant, mental healers and herbal medicine (WHO, 1996).

Traditional medicines are relatively inexpensive, locally available and are usually readily accepted by the local populace.

It was reported that about 60 – 85 percent of the population in developing countries depend on traditional or indigenous form of medicine (African Pharmacopoeia, 1985; Farnsworth, 1988). It is in recognition of these facts that the WHO has been attempting to incorporate traditional medicine officially into the health care systems of developing countries.

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