Phytochemical and Medicinal Properties of Extracts of the Leaves of Peucedanum Winkleri H. Wolff

Description

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Abstract

Phytochemical investigation of the leaves of Peucedanum winkleri. H. Wolff, revealed the presence of carbohydrates, free reducing sugar, cardiac glycoside, saponins, steroids, flavanoids, alkaloids, tannins and triterpenes.

The extracts were screened for their antimicrobial activity against Staphylococcus aureus, Methicillin resistant Staphylococcus aureus, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Corynebacterium ulcerans,

Klebsiella pneumoniae, Streptococcus pyogenes, Candida albicans, Candida tropicalis, Candida krusei and Proteus mirabilis. The result indicated that the extracts inhibited the growth of one or more test pathogens.

The ethyl acetate extract showed a broad spectrum of antimicrobial activity.4-(4-Chlorophenyl)-3-cyclohexyl-1-methyl-6-(2- naphthoyl)-1,2,3,4-tetrahydro-1,2,4,5-Tetrazine was isolated from the ethyl acetate extract of the plant leaves by means of Vacuum liquid chromatography (VLC),

Thin layer chromatography (TLC) and Preparative thin layer chromatography (PTLC) using a solvent mixture of 1:1 v/v petroleum-ether and ethyl acetate.

Introduction

Medicinal plants have always been associated with cultural behaviours and traditional knowledge. The renaissance of interest in plant products has been stimulated by the use of plant extracts in chronic conditions for which conventional drugs is perceived to offer very little specificity in its target (Rhiouani et al., 1999).

This has resulted in the use of large number of medicinal plants with curative properties to treat various diseases (Verpoorte, 1998).

Nearly 80% of the world‘s population relies on traditional medicines for primary health care, most of which involve the use of plant extracts (Akindele and Adeyemi, 2007).

The blind dependence on synthetics is over and people are returning to the naturals with hope of safety and security.

Also, the development of adverse effects and high microbial resistance to the chemically synthesized drugs, has forced men into ethnopharmacognosy.

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