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Studies Of Serum Electrolyte And Lipid Profile Among Type 2 Diabetic Patients In Owerri

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– Studies Of Serum Electrolyte And Lipid Profile Among Type 2 Diabetic Patients In Owerri –

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Abstract

A cross sectional comparative study was performed in Owerri metropolis to evaluate the serum electrolyte and lipid profile among type 2 diabetic patient and non diabetics.

A total of 60 subjects within age range 40-69 years were selected and grouped as diabetics and non diabetics (control) with 30 cases in each. Fasting serum lipid profile, glucose and electrolyte were measured using enzymatic kits.

Data were compared between diabetics and control and analyzed statistically by student independent t-test. The results show that total cholesterol was significantly (p<0.05) higher in diabetics (216.00 ± 11.67mg/dl) than Control (181.57 ± 12.94mg/dl).

Mean serum TG level was significantly (p˂ 0.05) higher in diabetics (149.27 ± 21.82mg/dl) than Control (113.80 ± 11.18mg/dl).

Introduction

Diabetes mellitus is a group of metabolic disorders that is characterized by elevated levels of glucose in blood (hyperglycemia) and insufficiency in production or action of insulin produced by the pancreas inside the body (Maritim et al., 2013).

Insulin is a protein (hormone) synthesized in beta cells of pancreas in response to various stimuli such as glucose, sulphonylureas, and arginine however glucose is the major determinant (Joshi et al., 2007).

Long term elevation in blood glucose levels is associated with macro- and micro-vascular complications leading to heart diseases, stroke, blindness and kidney diseases (Loghmani, 2015).

Sidewise to hyperglycemia, there are several other factors that play great role in pathogenesis of diabetes such as hyperlipidemia and oxidative stress leading to high risk of complications (Kangralkar et al., 2010).

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