Studies On Alterations Of Serum Proteins, Lipid Profile And Bilirubin Levels In Preeclamptic Women In Umuguma, Owerri

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– Studies On Alterations Of Serum Proteins, Lipid Profile And Bilirubin Levels In Preeclamptic Women In Umuguma, Owerri –

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Abstract

This study was carried out to determine the levels of proteins, bilirubin and lipid profile of pre-eclamptic patients attending Imo state specialist hospital, Umuguma. Sixty(60) subjects aged 25-40 years were recruited for the study and they were divided into two groups of thirty(30) pre-eclamptic women and thirty(30) apparently healthy pregnant women.

The sample was collected using a standard clean venipuncture technique and the statistical analysis was carried out using statistical package for social sciences(SPSS).

The result obtained showed a  significant decrease in total protein and albumin in pre-eclampsia women with mean values of 60.02±3.07g/l and 30.67±3.3g/l when compared with apparently healthy pregnant women with mean values of 65.69±4.9g/l and 36.30±2.9g/l at P<0.05.

In the bilirubin, both Total Bilirubin and Conjugated Bilirubin showed a significant increase in pre-eclamptic women with mean values of 0.7±0.15mg/dl and 0.22±0.097mg/dl when compared with the apparently healthy pregnant women with mean values 0.57±0.20mg/dl and 0.10±0.04mg/dl at P<0.05.

Introduction

For lipid profile, Total Cholesterol(Tc), Triglyceride(Tg) and Low Density Lipoprotein(LDL) showed a significant increase in Pre-eclamptic women with mean values of 231.34±18.59mg/dl,

162.32±25.40mg/dl and 176.65±27.26mg/dl when compared with the apparently healthy pregnant women with mean values of 201.79±16.63mg/dl, 84.47±8.69mg/dl and 54.18±4.49 mg/dl at P<0.05 .

While High Density Lipoprotein(HDL) shows a significant decrease in pre-eclamptic women with mean values of 44.27±4.11mg/dl when compared with the apparently healthy pregnant women with mean values of 49.50±7.25mg/dl at P<0.05.

This findings shows that pre-eclampsia is associated with hypoproteinaemia, hypoalbuminaemia, hyperbilirubinaemia and hyperlipidaemia Hence could probably serve as a biochemical marker in pre-eclampsia.

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