The Biochemical Effects of Cussonia Arborea Root Bark Extract in Alloxan-Induced Diabetic Rats

Description

– The Biochemical Effects of Cussonia Arborea Root Bark Extract in Alloxan-Induced Diabetic Rats –

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Abstract

Diabetes mellitus is a group of metabolic disorders characterized by chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. It is a growing public health concern worldwide affecting humans and animals.

Synthetic drugs available for the treatment of the ailment have serious side effects, complicated mode of intake and are costly. Literature search revealed that Cussonia arborea is used folklorically in the management of Diabetes mellitus.

The aim of this study is to isolate, characterize and elucidate the active principle responsible for its hypoglycaemic activity using alloxan-induced diabetic rats. The root bark of C. arborea (2 kg) was extracted with 80% methanol by cold maceration method.

Introduction

Diabetes is a complex and a multifarious group of metabolic disorders that disturbs the metabolism of carbohydrates, fats and protein (Kahn and Shechter, 1991; Bliss, 2000). It is characterized by increased fasting and postprandial blood glucose levels.

Diabetes mellitus is a group of metabolic disorder resulting from defects in insulin secretion or reduced sensitivity of the tissues to insulin action or both (Lanza et al., 2001). It is a disease characterized by inability to regulate blood glucose as a result of relative or absolute deficiency in insulin.

This results to hyperglycemia often accompanied by glycosuria, polydipsia and polyuria (Celik et al.,2002) Besides hyperglycaemia, several other factors like hyperlipidaemia and enhanced  oxidative stress play a major role in diabetes pathogenesis.

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