Toxic Profile of the Methanol Leaf Extract of Senna Siamea and its Antioxidant Prpoperties

Description

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Abstract

Medicinal plants have been assumed to be good in detoxifications because they contain bioactive compounds capable of doing this.

However, some plants are very toxic to both humans and animals with the potential of damaging certain organs in the body. Many plant- derived substances, collectively termed “phytochemicals,” are becoming increasingly known for their antioxidant activity.

This study is aimed at investigating the toxic and as well as the antioxidant profile of methanol extract of Senna siamea leaves, extensively used in Nigeria folk medicine to manage various ailments.

The potent metabolites were quantified using standard methods and the antioxidant scavenging potentials of the extract on DPPH and superoxide radicals were also determined.

Introduction

Medicinal plants are believed to be important sources of new chemical substances with potential therapeutic effects. Their activities depend on its phytochemical contents (Meyer et al., 1997).

Presently, it is estimated that about 80% of the world’s population are dependent on medicinal plants or plant-derived products for their health needs (Shri, 2003).

The use of medicinal plant is presently on the increase due to its availability, affordability, accessibility, and promising efficacy comparable to the often high cost and adverse effects associated with standard synthetic drug agents (Kwada and Tella, 2009).

One therefore expect bioactive compounds obtained from such plants to have low animal and human toxicity. However, people are often unaware of important similarities and differences between medicinal herbs and approved medications (Williamson et al., 1996).

Some mistakenly think of herbs as natural alternatives to chemicals, failing to recognize that herbs are composed of bioactive chemicals, some of which may be toxic (Fabricant and Farnsworth, 2001).

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