{"id":11653,"date":"2023-01-24T04:05:52","date_gmt":"2023-01-24T04:05:52","guid":{"rendered":"https:\/\/file.currentschoolnews.com\/?post_type=product&p=11653"},"modified":"2023-01-24T09:23:04","modified_gmt":"2023-01-24T09:23:04","slug":"design-and-development-of-a-starch-based-multifunctional-excipient-stargelasil-for-tablet-formulation","status":"publish","type":"product","link":"https:\/\/pastexamquestions.com\/product\/design-and-development-of-a-starch-based-multifunctional-excipient-stargelasil-for-tablet-formulation\/","title":{"rendered":"Design And Development of A Starch-Based Multifunctional Excipient (Stargelasil) For Tablet Formulation."},"content":{"rendered":"

Download Design and Development of a Starch-Based Multifunctional Excipient (Stargelasil) for Tablet Formulation<\/strong><\/span>. Pharmacognosy students who are writing their projects can get this material to aid their research work.<\/span><\/p>\n

Abstract<\/b><\/h2>\n

The concept<\/em> of co-processing<\/em> as a particle engineering<\/em> technique has been used as a tool to improve the functionality<\/em> of many existing excipients. This study was designed to improve the functionality<\/em> of cassava starch as excipient for direct compression by coprocessing with gelatin and colloidal silicon dioxide.<\/p>\n

The Design of Experiment (DoE) approach<\/em> was employed to optimize the percentage ratios of the primary<\/em> excipients for the co-processed excipient.<\/p>\n

Fourteen experimental formulations containing varying<\/em> proportions of the primary excipients were prepared by the method of co-fusion and twelve tablets each weighing 400 mg each were produced for each formulation using the Hydraulic<\/em> Carver Press.<\/p>\n

The compressed tablets were kept for 24 h in the desiccator and evaluated for tensile strength and disintegration time. The data obtained from the tablets were suitably analysed using the Design Expert software and fitted to a special quartic model that correlated the effect of varying the proportions of the excipients in the different formulations on tablet properties.<\/p>\n

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Introduction<\/span><\/span><\/strong><\/h2>\n

The European Pharmacopoeia (2002) defines tablets as solid preparations each containing a single dose of one or more active substances and usually obtained by compressing uniform volumes of particles.<\/p>\n

Tablets are intended for oral administration. Some are swallowed whole, some after being chewed, some are dissolved or dispersed in water before being administered and some are retained in the mouth where the active substance is liberated.<\/p>\n

Despite the long and continuing history of the development of new technologies for administration of drugs, the tablet form remains the most commonly used dosage form (European Pharmacopoeia, 2002).<\/p>\n

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