{"id":14468,"date":"2022-08-02T08:00:20","date_gmt":"2022-08-02T08:00:20","guid":{"rendered":"https:\/\/file.currentschoolnews.com\/?post_type=product&p=14468"},"modified":"2022-08-12T15:00:06","modified_gmt":"2022-08-12T15:00:06","slug":"gastroprotective-effects-of-zinc-and-vitamin-e-on-some-biochemical-and-histological-changes-on-ethanol-induced-mucosal-damage-in-wistar-rats","status":"publish","type":"product","link":"https:\/\/pastexamquestions.com\/product\/gastroprotective-effects-of-zinc-and-vitamin-e-on-some-biochemical-and-histological-changes-on-ethanol-induced-mucosal-damage-in-wistar-rats\/","title":{"rendered":"Gastroprotective Effects of Zinc and Vitamin E on Some Biochemical and Histological Changes on Ethanol-Induced Mucosal Damage in Wistar Rats"},"content":{"rendered":"

– Gastroprotective Effects of Zinc and Vitamin E on Some Biochemical and Histological Changes on Ethanol-Induced Mucosal Damage in Wistar Rats –<\/strong><\/span><\/p>\n

Download Gastroprotective Effects of Zinc and Vitamin E on Some Biochemical and Histological Changes on Ethanol-Induced Mucosal Damage in Wistar Rats<\/strong><\/span>. Students who are writing their projects can get this material to aid their research work.<\/span><\/span><\/p>\n

Abstract<\/strong><\/h3>\n

Antiulcerogenic effects of zinc, vitamin E and their combination on ethanol-induced ulcerogenic rats were investigated using standard methods.<\/p>\n

The rats treated with the combination of zinc and vitamin E, followed by those treated with zinc alone and those treated with the standard drug, cimetidine had significantly (P < 0.05) higher antiulcerogenic properties as indicated by their preventive indices of 92.44 %, 89.92 %, and 73.11 % respectively compared to the rats treated with vitamin E alone (49.58 %).<\/p>\n

Antioxidant studies revealed that vitamin E (10.01 \u00b1 0.54 \u03bcmol\/g tissue), zinc (8.77 \u00b1 0.55\u03bcmol\/g tissue) and their combination (8.52 \u00b1 0.87 \u03bcmol\/g tissue) exerted higher protective effects against lipid peroxidation, which was significantly (P < 0.05) lower than the ulcerogenic rats that were not treated and which had a value of 11.30 \u00b10.15 \u03bcmol\/g tissue.<\/p>\n

Superoxide dismutase (2.08 \u00b1 0.10 U\/g tissue) and glutathione peroxidase (43.17 \u00b1 0.38 U\/g tissue) activities increased significantly (P < 0.05) in the ulcerogenic groups treated with vitamin E, compared with the normal control group (1.63 \u00b1 0.14 U\/g tissue; 39.61 \u00b1 3.18 U\/g tissue).<\/p>\n

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Introduction<\/strong><\/h3>\n

1.1 Background of the Study<\/strong><\/p>\n

Zinc and vitamin E are important components of biological antioxidant systems (Sahin and Kucuk, 2003). Zinc is required for growth, optimum performance and modulation of immune system, partly due to its role as a co-factor of more than two hundred enzymes (Zago and Oteiza, 2001).<\/p>\n

An antioxidant is any agent that limits the deleterious effects of free-radical stimulated oxidant reactions. An example is vitamin E which terminates freeradical-initiated chain reactions by donating electrons to radicals (Burton and Traber, 1989).<\/p>\n

Zinc, however, limits oxidant-induced damage in other ways through stabilization of membranes, which increases membrane resistance to oxidant damage and may downregulate radical production. (DiSilvestro, 2000).<\/p>\n

The mechanism by which zinc exerts its antioxidant action is not well defined, but it has been suggested that it increases the synthesis of metallothionein, a cystein-rich protein, which acts as a free-radical scavenger` (Webb and Cain, 1982; Oteiza et al., 1996).<\/p>\n

Kim et al. (1998) proposed another mode of action for zinc as an antioxidant by studying its interaction with vitamin E because; vitamin E status is impaired in zinc-deficient animals (Kim et al., 1998).<\/p>\n

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