{"id":16159,"date":"2023-03-23T04:46:41","date_gmt":"2023-03-23T04:46:41","guid":{"rendered":"https:\/\/file.currentschoolnews.com\/?post_type=product&p=16159"},"modified":"2023-03-23T08:47:56","modified_gmt":"2023-03-23T08:47:56","slug":"pharmacological-evaluation-and-characterization-of-the-antiulcer-constituents-of-stem-bark-extract-of-bridelia-ferruginea-benth-euphorbiaceae","status":"publish","type":"product","link":"https:\/\/pastexamquestions.com\/product\/pharmacological-evaluation-and-characterization-of-the-antiulcer-constituents-of-stem-bark-extract-of-bridelia-ferruginea-benth-euphorbiaceae\/","title":{"rendered":"Pharmacological Evaluation and Characterization of the Antiulcer Constituents of Stem Bark Extract of Bridelia ferruginea Benth (Euphorbiaceae)"},"content":{"rendered":"

Download Pharmacological Evaluation and Characterization of the Antiulcer Constituents of Stem Bark Extract of Bridelia ferruginea Benth (Euphorbiaceae)<\/strong><\/span>. Pharmacology and Toxicology students who are writing their projects can get this material to aid their research work.<\/span><\/span><\/p>\n

Abstract<\/b><\/span><\/h2>\n

Peptic ulcer disease (PUD) is a sore in the lining of the stomach or duodenal mucosa. The search for an ideal antiulcer drug continues and has also been extended to medicinal plants. Bridelia ferruginea <\/em>Benth (Euphorbiaceae) is a plant used in traditional medical practice in South West Nigeria.<\/p>\n

This study was aimed at evaluating the antiulcer activity and mechanisms of the extract of the stem bark and to isolate the bioactive constituents responsible for the antiulcer activity.<\/p>\n

Methanol extract (ME) was obtained by cold maceration and concentration in vacuo<\/em>. ME was partitioned in chloroform-methanol-water (2:2:1) mixture to obtain the chloroform (CF) and aqueous methanol (AMF) fractions.<\/p>\n

The extract and fractions were subjected to biological activity-guided screening using indomethacin-induced ulcer as activity-guide.<\/p>\n

Based on higher ulcer protection given by CF, it was fractionated in a silica gel and eluted with gradient mixtures of n-hexane-ethyl acetate to obtain six broad fractions (I \u2013 VI). Fractions III and VI offered the highest protection on screening for biological activity.<\/p>\n

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Introduction<\/span><\/span><\/strong><\/span><\/h2>\n

Peptic ulcer is a sore that forms in the lining of the stomach or the duodenum. It encompasses gastric and duodenal ulcers and is the most prevalent gastrointestinal disorder (Prabha et al.<\/em>, 2011).<\/p>\n

Clinically, it presents as abdominal stress most often in the upper quandrant of the abdomen and epigastric region (Mayty, 2003; Ezekwesili et al., <\/em>2014). Peptic ulcer disease (PUD) is a chronic disease which impairs quality of life with increased morbidity and mortality (Shobha and Jamadar, 2013).<\/p>\n

It is associated with necrosis, infiltration of neutrophils, reduction in blood flow, and induction of oxidative stress as well as secretion of inflammatory mediators (De Souza et al.<\/em>, 2011; Viana et al., <\/em>2013).<\/p>\n

Ulceration refers to a process of inflammation in which an epithelial surface of the skin, gastric epithelium, colonic mucosa, and bladder epithelium has become necrotic and eroded, often associated with subepithelial acute and chronic inflammation (Tripathi, 2008; Yadav et al.<\/em>, 2013).<\/p>\n

PUD may manifest as superficial, deep or perforated erosions equal to or greater than 0.5 cm of the mucosal lining of the stomach, pyloric channels, duodenum and at or near the site of surgical anastomosis (post-operative ulcers) (Dhasan et al.<\/em>, 2010; Kalra et al.<\/em>, 2011).<\/p>\n

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