Effect of Aluminium Magnesium Silicate on Avian Influenza Virus sub Type H5n1

Description

– Effect of Aluminium Magnesium Silicate on Avian Influenza Virus sub Type H5n1 –

Download Effect of Aluminium Magnesium Silicate on Avian Influenza Virus sub Type H5n1. Veterinary Medicine students who are writing their projects can get this material to aid their research work.

Abstract

Effect of Aluminium – Magnesium Silicate (AMS) on Avian Influenza Virus was tested in vitro by incubating an isolate of a highly pathogenic Avian Influenza Virus (AIV) involved in an outbreak of the disease in Nigeria, with a synthetic AMS.

The isolate was a confirmed Influenza virus type A, subtype H5N1. An equal amount of the Virus sample and of the AMS, on a volume to weight (v/w) basis, were incubated at room temperature for one hour and then centrifuged at 3000 revolutions per minute.

The supernatant was tested for viral haemagglutination (HA) titre and for Mean Death Time (MDT) and Embryo Mortality rate (EMR) in embryonated chicken eggs.

Introduction

Viruses forming the Orthomyxoviridae have enveloped RNA viruses with single-stranded genome of negative sense (i.e. the virus RNA is complementary to the messenger RNA) which are divided into eight segments.

Proteins are associated with the RNA genome to form the nucleoprotein-RNA-polymerase complex (Jordan, 1999).

The matrix protein surrounding the genome complex is enveloped in a lipid membrane which is covered by two different surface projection proteins with which haemagglutinin and neuraminidase activities are associated, separately.

The gene for each of the structural proteins, or its precursor protein, is located on a separate genome segment.

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