Comparative Evaluation of the Ascorbic Acid Content of Mineral Ascorbate and Ascorbic Acid Tablets Marketed in Zaria

Description

– Comparative Evaluation of the Ascorbic Acid Content of Mineral Ascorbate and Ascorbic Acid Tablets Marketed in Zaria –

Download Comparative Evaluation of the Ascorbic Acid Content of Mineral Ascorbate and Ascorbic Acid Tablets Marketed in Zaria. Pharmaceutical And Medicinal Chemistry students who are writing their projects can get this material to aid their research work.

Abstract

The ascorbic acid content of mineral ascorbate and six brands of ascorbic acid tablets marketed in Zaria with brand names Calcium ascorbate, Ascorbion, Emvit C, Ascorvite, Topcee, Bioracee and Sofa C respectively were comparatively evaluated using four methods.

These include titrimetric method of British pharmacopoiea 2009, sodium thiosulphate titrimetric method, Ultra violet spectrophotometric method employing stabilizers and a newly developed 2,4- dinitrophenyl hydrazine method.

The developed method was validated and the analyte showed  an absorption maxima at 527nm and a percentage recovery of 97.4%.

Introduction

Vitamin C otherwise known as ascorbic acid is a water soluble vitamin that is naturally present in some foods, added to others and taken as a dietary supplement.

Though it is derived from glucose, humans and some other primates like guinea pigs, teleost, fishes, bats and birds cannot synthesize it invivo due to the genetic mutation that prevents them from synthesizing L-gluconolactone oxidase enzyme, which converts glucose to ascorbic acid.

Vitamin C can be synthesized by some other animals like dogs, goats, sheep, etc. (Storn, 1972).

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