Development and Validation of Four New Uv spectrometric Methods for the Determination of Isoniazid (Inh) In Pure and Tablet Dosage Forms

Description

– Development and Validation of Four New Uv spectrometric Methods for the Determination of Isoniazid (Inh) In Pure and Tablet Dosage Forms –

Download Development and Validation of Four New Uv spectrometric Methods for the Determination of Isoniazid (Inh) In Pure and Tablet Dosage Forms. Pharmaceutical Sciences students who are writing their projects can get this material to aid their research work.

Abstract

Tuberculosis (TB) is a serious infectious disease which is on increase since the emergence of the human immunodeficiency virus (HIV) leading to TB/HIV co-infection, causing complications and treatment failure. Isoniazid is a first-line drug for the treatment of TB therefore it is important to develop methods that will monitor its quality.

In this study, four rapid, simple, relatively accurate, and precise spectrophotometric methods for the quantitative determination of isoniazid in pure and tablet dosage form were developed and validated.

Methods 1 and 2 were based on dissolving standard isoniazid powder in distilled water and methanol respectively and scanning using UV-Vis spectrophotometer at a wavelength range of 200 – 400 nm to determine the wavelength of maximum absorption (λmax).

Introduction

Isoniazid (INH) also known as isonicotinyl hydrazide, is a synthetic derivative of isonicotinic acid hydrazide, chemically known as pyridine-4-carboxylic acid hydrazide (BP, 2009).

It is first-line drug in the treatment of pulmonary and extrapulmonary tuberculosis in combination with other anti-tubercular drugs such as rifampicin, ethambutol, pyrazinamide, and streptomycin to avoid the development of resistance(WHO, 2010, Niraimathi et al., 2013).

Isoniazid is a pro-drug and requires activation by the bacterial catalase-peroxidase enzyme (BP, 2009). HPLC is the most sensitive and selective means of determining isoniazid in its pure and tablet dosage form and methods have been reported (Khuhawret al., 2005;Milan-Segovia et al., 2007;

Dhal and Sharma, 2009; Abdallah et al., 2016). However, the cost of procurement and the technical hands to operate the HPLC machine is a major challenge in most developing countries.

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