Formulation and Optimization of Artemether And Lumefantrine Calcium Alginate Capsules Using Inverse Gelation Technique

Description

– Formulation and Optimization of Artemether And Lumefantrine Calcium Alginate Capsules Using Inverse Gelation Technique –

Download Formulation and Optimization of Artemether And Lumefantrine Calcium Alginate Capsules Using Inverse Gelation Technique. Pharmaceutical Sciences students who are writing their projects can get this material to aid their research work.

Abstract

Poorly water-soluble drug candidates are associated with dissolution, absorption and bioavailability challenges. Consequently, poor solubility and non-reproducible absorption from the gastrointestinal tract following oral administration constitute a biopharmaceutical concern to dosage form design and formulation.

The use of lipid-based formulations to address this concern has been the choice of many scientists in the drug delivery domain.

Artemether and Lumefantrine the drugs investigated in the work are poorly soluble with unpredictable absorption and bioavailability problems. In addition, they may be prone to acid hydrolysis and precipitation respectively in gastric environment of the stomach.

To date there is no published work on alginate capsules geared towards solving bioavailability problems and inactivation of Artemether and Lumefantrine in the stomach.

Introduction

Drug delivery refers to different ways of administering drugs to the body needed to safely achieve its desired therapeutic effect. It involves targeting a drug to a particular site within the body. Drug delivery is often approached via a drug’s chemical formulation, but it may also involve medical devices or drug-device combination products.

Drug delivery is a concept heavily integrated with dosage form and route of administration, the latter sometimes even being considered part of the definition.

Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Drug release is from: diffusion, degradation, swelling, and affinity-based mechanisms. 

Most common routes of administration include the preferred non-invasive peroral (through the mouth), topical (skin), transmucosal (nasal, buccal/sublingual, vaginal, ocular and rectal) and inhalation routes.

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