Studies on In-Vivo Antioxidant and Hepatoprotective of Citrus Sinensis (L.) Osbeck Peel Extract in Wistar Rats

Description

Download Studies on In-Vivo Antioxidant and Hepatoprotective of Citrus Sinensis (L.) Osbeck Peel Extract in Wistar Rats. Pharmacy students who are writing their projects can get this material to aid their research work.

Abstract

Citrus sinensis is the commonest, most widely cultivated, and consumed citrus fruit. Large amounts of peel wastes are formed when citrus is consumed or processed, and suitable methods have to be adopted to utilize these waste materials for conversion into value-added products.

Flavonoids, the major component of citrus peel have been reported to exert antioxidant and hepatoprotective activity.

This study was designed to investigate the in-vivo antioxidant and hepatoprotective properties of the methanol extract of citrus fruit peel in Wistar rats.

Introduction

During normal metabolism, body cells use oxygen and in the process generate highly reactive molecules known as free radicals capable of abstracting electrons (oxidation) from neighbouring cells (Moreira da Silva et al., 2010)

Oxidative stress is created when excessive free radicals react with proteins, cell walls, and DNA causing damage to cell structures that are critical to the immune system (Xiuzhen et al., 2007).

Free radicals can also be produced by inflammatory responses, stress, and environmental pollution.

When these free radicals are not removed and cell damage is not repaired, cell death occurs leading to a higher propensity for disease (Halliwell, 1992).

Many drugs, toxic substances, and infectious organisms are associated with hepatotoxicity due to their ability to generate free radicals and to cause a disturbance in hepatocyte biochemistry (Fernandez-Checa and Kaplowitz, 2005).

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